In this study, an empirical study was conducted to investigate the clean air delivery rate (CADR) and the proper particle cleaned air delivery per hour (PCH) of the air cleaning device installed in passenger car cabin. Changes in internal particle concentration were measured in the cabins of the pick-up type engine-driven car and the electric vehicle depending on cabin air filters, ventilation modes, and blower settings. In the tested cars, PM2.5 collection efficiency of the HEPA filter was higher than that of the genuine filter. The PM2.5 collection efficiency of each cabin air filter was measured to be similar regardless of the blower setting of the tested cars. This means that the higher the blower setting, the higher the CADR and the PCH. The infiltration rate varies depending on the air tightness of the car. The cabin was more contaminated with particles under driving. From the CADRs measured inside the passenger car cabin, the recirculation mode of HVAC system is a more effective for managing ultrafine particles than the fresh air mode. From a few assumptions, the proper PCH was derived about 0.8 times/min (48 times/h). From this result and several experiments, the proper operation setting of air cleaning device installed inside cars can be found out to control indoor air quality. Also, an appropriate operation settings of HVAC system can be found with considering cooling and heating conditions for thermal comfort in passenger car cabin.